In this research, there is the study of the SMES in a region of the Mexican Southeast, from a optical quantitative and qualitative, in virtue of the requirement of in-depth studies in specific contexts, due to the dizzying transformations that occurs throughout the world in economic matters and labor force. The theoretical level focuses on two positions that are discussed in the international framework: a) those who said the disappearance of these companies and the figure of the employer before the strength of the shareholder capital in the global economy and (b) those who opted for the prevalence of this, increasingly large. In terms of quality approach, interviewing staff and managers of the public sector and retrieves the voice of the associations and chambers of commerce, to detect how it manifests itself in each entity the weakness of SMES, in response to various economic and social factors.