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Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

dc.contributorANDREA STRAKOVA
dc.contributorMAIRE NI LEATHLOBHAIR
dc.contributorGUO DONG WANG
dc.contributorTING TING YIN
dc.contributorILONA AIRIKKALA OTTER
dc.contributorJANICE L. ALLEN
dc.contributorKAREN M. ALLUM
dc.contributorLEONTINE BANSSE ISSA
dc.contributorJOCELYN L. BISSON
dc.contributorARTEMIO CASTILLO DOMRACHEVA
dc.contributorKARINA F. DE CASTRO
dc.contributorANNE M. CORRIGAN
dc.contributorHUGH R. CRAN
dc.contributorJANE T. CRAWFORD
dc.contributorSTEPHEN M. CUTTER
dc.contributorLAURA DELGADILLO KEENAN
dc.contributorEDWARD M. DONELAN
dc.contributorIBIKUNLE A. FARAMADE
dc.contributorERIKA FLORES REYNOSO
dc.contributorELENI FOTOPOULOU
dc.contributorSKYE N. FRUEAN
dc.contributorFANNY GALLARDO ARRIETA
dc.contributorOLGA GLEBOVA
dc.contributorRODRIGO F. HAFELIN MANRIQUE
dc.contributorJOAQUIM J. G. P. HENRIQUES
dc.contributorNATALIA IGNATENKO
dc.contributorDEBBIE KOENIG
dc.contributorMARTA LANZA PEREA
dc.contributorREMO LOBETTI
dc.contributorADRIANA M. LOPEZ QUINTANA
dc.contributorTHIBAULT LOSFELT
dc.contributorGABRIELE MARINO
dc.contributorINIGO MARTINCORENA
dc.contributorMAYRA F. MARTINEZ LOPEZ
dc.contributorMICHAEL MEYER
dc.contributorBERNA NAKANWAGI
dc.contributorANDRIGO B. DE NARDI
dc.contributorWINIFRED NEUNZIG
dc.contributorSALLY J. NIXON
dc.contributorMARSDEN M. ONSARE
dc.contributorMARIA C. PELETEIRO
dc.contributorRUTH J. PYE
dc.contributorJOHN F. REECE
dc.contributorJOSE ROJAS GUTIERREZ
dc.contributorHALEEMA SADIA
dc.contributorSHEILA K. SCHMELING
dc.contributorOLGA SHAMANOVA
dc.contributorRICHARD K. SSUNA
dc.contributorAUDREY E. STEENLAND SMIT
dc.contributorALLA SVITICH
dc.contributorISMAIL THOYA NGOKA
dc.contributorBODGAN A. VITALARU
dc.contributorANNA P. DE VOS
dc.contributorJOHAN P. DE VOS
dc.contributorOLIVER WALKINTON
dc.contributorDAVID C. WEDGE
dc.contributorALVARO SEBASTIAN WEHRLE MARTINEZ
dc.contributorMIRJAM G. VAN DER WEL
dc.contributorSOPHIE A. E. WIDDOWSON
dc.contributorELIZABETH P. MURCHISON
dc.coverage.spatialGeneración de conocimiento
dc.creatorANTONIO ORTEGA PACHECO
dc.creatorJOSE SIMON MARTINEZ CASTAÑEDA
dc.date2016-05-17
dc.date.accessioned2018-10-04T15:25:23Z
dc.date.available2018-10-04T15:25:23Z
dc.identifierhttps://dx.doi.org/10.7554/eLife.14552
dc.identifier.urihttp://redi.uady.mx:8080/handle/123456789/1468
dc.description.abstractCanine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.
dc.languageeng
dc.publishereLife
dc.relationcitation:0
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceurn:issn:2050-084x
dc.subjectinfo:eu-repo/classification/cti/2
dc.subjectBIOLOGÍA Y QUÍMICA
dc.subjectinfo:eu-repo/classification/cti/3
dc.subjectMEDICINA Y CIENCIAS DE LA SALUD
dc.titleMitochondrial genetic diversity, selection and recombination in a canine transmissible cancer
dc.typeinfo:eu-repo/semantics/article


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